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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISL2ISL LIM homeobox 2b. (364 aa)    
Predicted Functional Partners:
LHX3
LIM homeobox 3.
   
0.766
lhx4
LIM homeobox 4.
   
0.757
I3IYF2_ORENI
LIM domain binding 2a.
    
 0.680
I3JSU9_ORENI
LIM domain binding 1a.
    
 0.680
LOC100706951
LIM-domain binding 1b.
    
 0.680
ascl1
Achaete-scute family bHLH transcription factor 1a.
   
 0.490
barx1
BARX homeobox 1.
   
 
 0.447
Vsx1
Visual system homeobox 1 homolog, chx10-like.
   
  
 0.446
nkx2-5
NK2 homeobox 5.
    
 
 0.431
ptf1a
Pancreas associated transcription factor 1a.
   
 0.425
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.