LOC100705111 protein (Oreochromis niloticus)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

LOC100705111

Immunoglobulin superfamily, DCC subclass, member 4. (1233 aa)

Predicted Functional Partners:

appl1

0.941

appl2

0.941

NTN1

0.785

LOC100703122

0.785

LOC100698643

0.785

LOC100711643

0.785

I3J1I3_ORENI

0.679

I3JB83_ORENI

0.679

casp9

0.671

draxin

0.660

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3J1I3_ORENI	LOC100703122	ENSONIP00000002723	ENSONIP00000023890	Hemojuvelin BMP co-receptor.	Netrin 5.	0.403
I3J1I3_ORENI	LOC100705111	ENSONIP00000002723	ENSONIP00000003344	Hemojuvelin BMP co-receptor.	Immunoglobulin superfamily, DCC subclass, member 4.	0.679
I3JB83_ORENI	LOC100705111	ENSONIP00000006123	ENSONIP00000003344	RGM domain family, member D.	Immunoglobulin superfamily, DCC subclass, member 4.	0.679
LOC100698643	LOC100705111	ENSONIP00000025223	ENSONIP00000003344	Netrin 2.	Immunoglobulin superfamily, DCC subclass, member 4.	0.785
LOC100698643	draxin	ENSONIP00000025223	ENSONIP00000000770	Netrin 2.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	0.692
LOC100703122	I3J1I3_ORENI	ENSONIP00000023890	ENSONIP00000002723	Netrin 5.	Hemojuvelin BMP co-receptor.	0.403
LOC100703122	LOC100705111	ENSONIP00000023890	ENSONIP00000003344	Netrin 5.	Immunoglobulin superfamily, DCC subclass, member 4.	0.785
LOC100703122	draxin	ENSONIP00000023890	ENSONIP00000000770	Netrin 5.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	0.652
LOC100705111	I3J1I3_ORENI	ENSONIP00000003344	ENSONIP00000002723	Immunoglobulin superfamily, DCC subclass, member 4.	Hemojuvelin BMP co-receptor.	0.679
LOC100705111	I3JB83_ORENI	ENSONIP00000003344	ENSONIP00000006123	Immunoglobulin superfamily, DCC subclass, member 4.	RGM domain family, member D.	0.679
LOC100705111	LOC100698643	ENSONIP00000003344	ENSONIP00000025223	Immunoglobulin superfamily, DCC subclass, member 4.	Netrin 2.	0.785
LOC100705111	LOC100703122	ENSONIP00000003344	ENSONIP00000023890	Immunoglobulin superfamily, DCC subclass, member 4.	Netrin 5.	0.785
LOC100705111	LOC100711643	ENSONIP00000003344	ENSONIP00000035112	Immunoglobulin superfamily, DCC subclass, member 4.	Netrin 1b.	0.785
LOC100705111	NTN1	ENSONIP00000003344	ENSONIP00000022872	Immunoglobulin superfamily, DCC subclass, member 4.	Netrin 1.	0.785
LOC100705111	appl1	ENSONIP00000003344	ENSONIP00000048064	Immunoglobulin superfamily, DCC subclass, member 4.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.941
LOC100705111	appl2	ENSONIP00000003344	ENSONIP00000068145	Immunoglobulin superfamily, DCC subclass, member 4.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.941
LOC100705111	casp9	ENSONIP00000003344	ENSONIP00000008378	Immunoglobulin superfamily, DCC subclass, member 4.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.671
LOC100705111	draxin	ENSONIP00000003344	ENSONIP00000000770	Immunoglobulin superfamily, DCC subclass, member 4.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	0.660
LOC100711643	LOC100705111	ENSONIP00000035112	ENSONIP00000003344	Netrin 1b.	Immunoglobulin superfamily, DCC subclass, member 4.	0.785
LOC100711643	draxin	ENSONIP00000035112	ENSONIP00000000770	Netrin 1b.	Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.	0.652

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.739

expected number of edges:

12

PPI enrichment p-value:

8.67e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008360

Regulation of cell shape

6 of 118

1.96

2.95

2.83e-07

GO:0007163

Establishment or maintenance of cell polarity

6 of 162

1.82

2.59

8.96e-07

GO:0030865

Cortical cytoskeleton organization

4 of 51

2.14

2.36

1.99e-05

GO:0032956

Regulation of actin cytoskeleton organization

6 of 286

1.57

1.96

8.33e-06

GO:0030036

Actin cytoskeleton organization

7 of 487

1.41

1.76

5.20e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

4 of 287

1.39

0.64

0.0437

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043296

Apical junction complex

4 of 115

1.79

1.52

0.00064

GO:0005911

Cell-cell junction

5 of 376

1.37

1.2

0.00088

GO:0005938

Cell cortex

4 of 238

1.48

1.08

0.0036

GO:0005923

Bicellular tight junction

3 of 96

1.74

1.05

0.0078

GO:0005856

Cytoskeleton

7 of 1958

0.8

0.56

0.0078

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14053

Mixed, incl. Small GTPase Rho, and RHOU GTPase cycle

3 of 65

1.91

0.81

0.0285

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fca04530

Tight junction

7 of 146

1.93

3.97

1.66e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2173791

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

3 of 15

2.55

2.02

0.00018

MAP-416572

Sema4D induced cell migration and growth-cone collapse

2 of 9

2.6

1.31

0.0040

MAP-400685

Sema4D in semaphorin signaling

2 of 12

2.47

1.26

0.0049

MAP-9012999

RHO GTPase cycle

6 of 577

1.27

1.23

0.00024

MAP-416482

G alpha (12/13) signalling events

3 of 85

1.8

1.19

0.0040

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070161

Anchoring junction

5 of 306

1.46

1.29

0.00077

GOCC:0070160

Tight junction

3 of 56

1.98

1.24

0.0039

GOCC:0005911

Cell-cell junction

4 of 219

1.51

1.08

0.0039

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

4 of 170

1.62

1.41

0.00073

KW-0547

Nucleotide-binding

5 of 961

0.97

0.59

0.0200

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003578

Small GTPase Rho

4 of 22

2.51

2.78

5.67e-06

IPR001806

Small GTPase

4 of 130

1.74

1.26

0.0024

IPR005225

Small GTP-binding protein domain

4 of 151

1.67

1.21

0.0028

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

4 of 20

2.55

3.34

4.66e-07

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