Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DENND3DENN domain containing 3. (1295 aa)    
Predicted Functional Partners:
rab12
RAB12, member RAS oncogene family.
    
 0.877
RAB28
RAB28, member RAS oncogene family.
    
 0.614
LOC100690604
Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.
     
 0.605
ncln
Nicalin.
      
 0.573
ulk1
Unc-51 like autophagy activating kinase 1.
    
  0.572
ulk2
Unc-51 like autophagy activating kinase 2.
    
  0.572
LOC100699294
Unc-51 like autophagy activating kinase 1a.
    
  0.572
tbata
Thymus, brain and testes associated.
      
 0.561
lmod1
Leiomodin 1b (smooth muscle).
      
 0.507
dennd5a
DENN/MADD domain containing 5A.
    
 
 0.504
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (28%) [HD]