Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lrrc49Leucine-rich repeat-containing protein 49 isoform X1. (806 aa)    
Predicted Functional Partners:
tpgs1
Uncharacterized protein.
    
 0.903
ttll1
Tubulin tyrosine ligase-like family, member 1.
   
 0.898
Tpgs2
Tubulin polyglutamylase complex subunit 2.
    
 0.896
nicn1
Nicolin 1.
    
 0.889
lg7h11orf49
Zgc:92873.
    
 
 0.859
tbc1d19
TBC1 domain family, member 19.
   
   0.778
EIF3S5
Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
    
  0.774
kiaa1841
Si:ch211-189k9.2.
    
   0.772
ttl
Tubulin tyrosine ligase.
   
 0.710
I3JR68_ORENI
NME/NM23 family member 8; Belongs to the NDK family.
    
 0.615
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (14%) [HD]