Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LOC100707581Tyrosine-protein kinase receptor. (1423 aa)    
Predicted Functional Partners:
I3KMU3_ORENI
Insulin-like growth factor 1.
    
 0.967
LOC100704156
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.958
ENSONIP00000069434
annotation not available
    
 0.955
irs2
Insulin receptor substrate 2b.
    
 0.949
I3KAU3_ORENI
Insulin-like growth factor 2b.
    
 0.940
LOC100704325
Insulin receptor substrate 2a.
    
 0.937
I3JB37_ORENI
Si:ch73-335l21.1.
    
 0.937
I3J8S9_ORENI
Si:ch211-284e13.4.
    
 0.937
SHC3
SHC adaptor protein 3.
    
 0.936
LOC100696779
SHC (Src homology 2 domain containing) transforming protein 2.
    
 0.934
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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