Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lgr4Leucine-rich repeat containing G protein-coupled receptor 4. (978 aa)    
Predicted Functional Partners:
Rspo3
R-spondin 3.
   
 0.989
Znrf3
Zinc and ring finger 3.
    
 0.989
Rspo1
R-spondin 1.
   
 0.974
rspo2
R-spondin 2.
   
 0.965
LOC100692626
Uncharacterized protein.
   
 0.956
ENSONIP00000053255
annotation not available
   
 0.948
Rnf43
E3 ubiquitin-protein ligase RNF43.
    
 0.947
LGR5
Leucine rich repeat containing G protein-coupled receptor 5.
    
  0.925
LGR6
Leucine rich repeat containing G protein-coupled receptor 6.
    
  0.917
ENSONIP00000018453
Hemicentin-2-like isoform X1.
    
 0.911
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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