Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dhcr77-dehydrocholesterol reductase. (472 aa)    
Predicted Functional Partners:
dhcr24
24-dehydrocholesterol reductase.
 
 
 0.997
sc5d
Sterol-C5-desaturase; Belongs to the sterol desaturase family.
   
 0.995
LOC100696185
Delta7-sterol 5-desaturase.
   
 0.986
Sqle
Squalene epoxidase a.
   
 
 0.984
LOC100702293
Cytochrome P450, family 51; Belongs to the cytochrome P450 family.
   
 0.978
nsdhl
NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.
   
 
 0.957
LOC100709377
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 0.956
LOC100696013
Cholesterol 25-hydroxylase like 3; Belongs to the sterol desaturase family.
   
 0.952
LOC100704054
Cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4; Belongs to the cytochrome P450 family.
   
 0.949
I3KE17_ORENI
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
    
 0.937
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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