Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC100692227RING-CH-type domain-containing protein. (248 aa)    
Predicted Functional Partners:
ube2g2
Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.564
c1qtnf12
C1q and TNF related 12.
    
 
 0.476
ube2j2
Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast).
    
 
 0.476
I3JA42_ORENI
Syntaxin 6; Belongs to the syntaxin family.
    
 
 0.470
I3IV58_ORENI
Syntaxin 10.
    
 
 0.470
UBR1
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
 
 0.460
Ubr2
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
 
 0.460
CNOT2
CCR4-NOT transcription complex subunit 2.
    
 
 0.448
LOC100705067
CCR4-NOT transcription complex, subunit 2.
    
 
 0.448
ufd1
Ubiquitin recognition factor in ER associated degradation 1.
    
 
 0.446
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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