Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Ccne1Cyclin E1; Belongs to the cyclin family. (296 aa)    
Predicted Functional Partners:
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.990
rb1
Retinoblastoma 1.
   
 0.986
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
   
 0.985
rbl1
Retinoblastoma-like 1 (p107).
   
 0.976
LOC100692495
Retinoblastoma-like 2 (p130).
   
 0.976
LOC102082412
Cyclin-dependent kinase inhibitor 1A.
   
 0.976
LOC100711644
Cyclin-dependent kinase inhibitor 1Cb.
   
 0.975
cdkn1b
Cyclin-dependent kinase inhibitor 1Bb.
   
 0.971
LOC100698501
Uncharacterized protein.
   
 0.971
ENSONIP00000041766
Cyclin-dependent kinase inhibitor 1B.
   
 0.971
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.