Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC100701023WW domain containing E3 ubiquitin protein ligase 1. (961 aa)    
Predicted Functional Partners:
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.932
LOC100711613
Receptor protein-tyrosine kinase.
    
 0.931
egfr
Receptor protein-tyrosine kinase.
    
 0.931
Fgfr2
Fibroblast growth factor receptor.
    
  0.921
pdgfra
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
    
  0.917
ENSONIP00000073168
Fibroblast growth factor receptor 1.
    
  0.909
LOC100707581
Tyrosine-protein kinase receptor.
    
 0.888
LOC100711993
Tyrosine-protein kinase receptor.
    
 0.888
I3JEG4_ORENI
NEDD4 E3 ubiquitin protein ligase a.
    
  0.888
ENSONIP00000069434
annotation not available
    
 0.882
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.