Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PPM1LProtein phosphatase, Mg2+/Mn2+ dependent 1L. (357 aa)    
Predicted Functional Partners:
bckdhb
Branched chain keto acid dehydrogenase E1 subunit beta.
   
 0.785
dbt
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
   
 0.780
bckdha
2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
   
 0.730
I3JR68_ORENI
NME/NM23 family member 8; Belongs to the NDK family.
  
 0.712
vapb
VAMP (vesicle-associated membrane protein)-associated protein B and C.
   
 0.631
LOC100689790
RAB33B, member RAS oncogene family a.
   
  
 0.631
vapa
VAMP (vesicle-associated membrane protein)-associated protein A, like.
   
 0.631
cstf1
Cleavage stimulation factor, 3' pre-RNA, subunit 1.
      
 0.625
tbc1d16
TBC1 domain family, member 16.
      
 0.614
acbd3
Acyl-Coenzyme A binding domain containing 3.
   
  
 0.607
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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