gtf3c3 protein (Oreochromis niloticus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

gtf3c3

General transcription factor IIIC, polypeptide 3. (932 aa)

Predicted Functional Partners:

gtf3c5

0.999

polr3d

0.991

BRF1

0.970

LOC100698875

0.970

cpsf2

0.969

bdp1

0.968

cpsf1

0.967

brf2

0.960

LOC100697816

0.952

gtf3c2

0.946

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRF1	LOC100697816	ENSONIP00000000315	ENSONIP00000009181	BRF1 RNA polymerase III transcription initiation factor subunit b.	Zgc:171971.	0.823
BRF1	bdp1	ENSONIP00000000315	ENSONIP00000075875	BRF1 RNA polymerase III transcription initiation factor subunit b.	Transcription factor TFIIIB component B'' homolog isoform X1.	0.970
BRF1	gtf3c2	ENSONIP00000000315	ENSONIP00000013273	BRF1 RNA polymerase III transcription initiation factor subunit b.	General transcription factor IIIC, polypeptide 2, beta.	0.528
BRF1	gtf3c3	ENSONIP00000000315	ENSONIP00000004756	BRF1 RNA polymerase III transcription initiation factor subunit b.	General transcription factor IIIC, polypeptide 3.	0.970
BRF1	gtf3c5	ENSONIP00000000315	ENSONIP00000078520	BRF1 RNA polymerase III transcription initiation factor subunit b.	General transcription factor IIIC, polypeptide 5.	0.860
BRF1	polr3d	ENSONIP00000000315	ENSONIP00000079773	BRF1 RNA polymerase III transcription initiation factor subunit b.	Polymerase (RNA) III (DNA directed) polypeptide D.	0.913
LOC100697816	BRF1	ENSONIP00000009181	ENSONIP00000000315	Zgc:171971.	BRF1 RNA polymerase III transcription initiation factor subunit b.	0.823
LOC100697816	LOC100698875	ENSONIP00000009181	ENSONIP00000034205	Zgc:171971.	Uncharacterized protein.	0.823
LOC100697816	bdp1	ENSONIP00000009181	ENSONIP00000075875	Zgc:171971.	Transcription factor TFIIIB component B'' homolog isoform X1.	0.933
LOC100697816	brf2	ENSONIP00000009181	ENSONIP00000028741	Zgc:171971.	BRF2 RNA polymerase III transcription initiation factor subunit.	0.823
LOC100697816	gtf3c3	ENSONIP00000009181	ENSONIP00000004756	Zgc:171971.	General transcription factor IIIC, polypeptide 3.	0.952
LOC100697816	gtf3c5	ENSONIP00000009181	ENSONIP00000078520	Zgc:171971.	General transcription factor IIIC, polypeptide 5.	0.757
LOC100697816	polr3d	ENSONIP00000009181	ENSONIP00000079773	Zgc:171971.	Polymerase (RNA) III (DNA directed) polypeptide D.	0.445
LOC100698875	LOC100697816	ENSONIP00000034205	ENSONIP00000009181	Uncharacterized protein.	Zgc:171971.	0.823
LOC100698875	bdp1	ENSONIP00000034205	ENSONIP00000075875	Uncharacterized protein.	Transcription factor TFIIIB component B'' homolog isoform X1.	0.970
LOC100698875	gtf3c2	ENSONIP00000034205	ENSONIP00000013273	Uncharacterized protein.	General transcription factor IIIC, polypeptide 2, beta.	0.528
LOC100698875	gtf3c3	ENSONIP00000034205	ENSONIP00000004756	Uncharacterized protein.	General transcription factor IIIC, polypeptide 3.	0.970
LOC100698875	gtf3c5	ENSONIP00000034205	ENSONIP00000078520	Uncharacterized protein.	General transcription factor IIIC, polypeptide 5.	0.860
LOC100698875	polr3d	ENSONIP00000034205	ENSONIP00000079773	Uncharacterized protein.	Polymerase (RNA) III (DNA directed) polypeptide D.	0.913
bdp1	BRF1	ENSONIP00000075875	ENSONIP00000000315	Transcription factor TFIIIB component B'' homolog isoform X1.	BRF1 RNA polymerase III transcription initiation factor subunit b.	0.970

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.968

expected number of edges:

10

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045039

Protein insertion into mitochondrial inner membrane

3 of 7

3.0

2.53

2.54e-05

GO:0046834

Lipid phosphorylation

2 of 2

3.37

1.79

0.00060

GO:0046512

Sphingosine biosynthetic process

2 of 5

2.97

1.59

0.0013

GO:0006121

Mitochondrial electron transport, succinate to ubiquinone

2 of 6

2.89

1.59

0.0013

GO:0006099

Tricarboxylic acid cycle

2 of 29

2.2

1.05

0.0111

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140318

Protein transporter activity

3 of 25

2.44

1.87

0.00032

GO:0004402

Histone acetyltransferase activity

2 of 23

2.3

0.85

0.0274

GO:0140110

Transcription regulator activity

4 of 412

1.35

0.78

0.0171

GO:0046872

Metal ion binding

6 of 2233

0.79

0.46

0.0331

GO:0005488

Binding

10 of 7866

0.47

0.32

0.0274

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042721

TIM22 mitochondrial import inner membrane insertion complex

3 of 4

3.24

3.32

9.53e-07

GO:0098800

Inner mitochondrial membrane protein complex

5 of 120

1.99

2.79

9.53e-07

GO:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 3

3.19

2.13

0.00014

GO:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

2 of 5

2.97

1.98

0.00026

GO:0032991

Protein-containing complex

6 of 2897

0.68

0.45

0.0164

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24142

Tim10-like, and TIM22 mitochondrial import inner membrane insertion complex

3 of 7

3.0

2.59

1.96e-05

CL:19911

Fumarate reductase complex

2 of 5

2.97

1.48

0.0021

CL:1544

Mixed, incl. Lectin, and Met-10+ like-protein

2 of 11

2.63

1.31

0.0040

CL:21436

Sphingolipid metabolism

2 of 18

2.41

1.12

0.0088

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

2 of 49

1.98

0.79

0.0330

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 72

1.99

1.25

0.0037

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 4

3.06

1.6

0.0013

GOCC:0045281

Succinate dehydrogenase complex

2 of 7

2.82

1.52

0.0017

GOCC:0098798

Mitochondrial protein complex

4 of 184

1.7

1.42

0.00090

GOCC:0005740

Mitochondrial envelope

4 of 367

1.4

1.12

0.0019

GOCC:0098800

Inner mitochondrial membrane protein complex

2 of 75

1.79

0.82

0.0255

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 13

2.55

1.41

0.0026

KW-0496

Mitochondrion

3 of 102

1.83

1.28

0.0026

KW-1015

Disulfide bond

2 of 92

1.7

0.7

0.0428

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02953

Tim10/DDP family zinc finger

2 of 4

3.06

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034804

Fumarate reductase/succinate dehydrogenase, transmembrane subunit

2 of 3

3.19

1.39

0.0032

IPR001206

Diacylglycerol kinase, catalytic domain

2 of 2

3.37

1.39

0.0032

IPR035427

Tim10-like domain superfamily

2 of 4

3.06

1.38

0.0032

IPR017438

Inorganic polyphosphate/ATP-NAD kinase, N-terminal

2 of 5

2.97

1.38

0.0032

IPR016064

NAD kinase/diacylglycerol kinase-like domain superfamily

2 of 5

2.97

1.38

0.0032

(more ...)

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