STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lrrk2Leucine-rich repeat kinase 2. (2443 aa)    
Predicted Functional Partners:
Prkn
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.
    
 
 0.658
vps35
Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.
    
 
 0.642
LOC100691213
Uncharacterized protein; Belongs to the synuclein family.
    
 
 0.602
park7
Parkinson protein 7.
    
 
 0.585
pink1
PTEN induced kinase 1.
      
 0.566
I3JQJ5_ORENI
Adhesion G protein-coupled receptor L3.1; Belongs to the G-protein coupled receptor 2 family.
    
   0.530
LOC100702950
Si:ch1073-186i23.1; Belongs to the G-protein coupled receptor 2 family.
    
   0.530
I3KHL0_ORENI
Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.
    
   0.530
adgrl2
Adhesion G protein-coupled receptor L2a; Belongs to the G-protein coupled receptor 2 family.
    
   0.530
ADGRL3
Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.
    
   0.530
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.