Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
I3J7X5_ORENITIR domain-containing protein; Belongs to the Toll-like receptor family. (576 aa)    
Predicted Functional Partners:
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
 0.808
unc93b1
Unc-93 homolog B1, TLR signaling regulator.
    
 0.716
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.695
irak4
Interleukin-1 receptor-associated kinase 4.
    
 0.676
irak1
Interleukin-1 receptor-associated kinase 1.
    
 0.662
LOC100701005
Transmembrane p24 trafficking protein 7.
    
 0.600
LOC100701239
TRIF-NTD domain-containing protein.
    
 0.600
ripk1
Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.
    
 0.583
tirap
Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.
   
 0.539
LOC100696189
Toll-like receptor 9; Belongs to the Toll-like receptor family.
     
  0.480
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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