Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC100707821Oxysterol-binding protein; Belongs to the OSBP family. (818 aa)    
Predicted Functional Partners:
gak
Cyclin G associated kinase.
   
 
 0.614
vapb
VAMP (vesicle-associated membrane protein)-associated protein B and C.
    
 
 0.520
vapa
VAMP (vesicle-associated membrane protein)-associated protein A, like.
    
 
 0.520
casp9
Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
      
 0.519
apaf1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
      
 0.519
ndufa12
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
   
  
 0.488
agbl5
ATP/GTP binding protein-like 5.
      
 0.483
LOC100711919
MSP domain-containing protein.
    
 
 0.482
I3J8T9_ORENI
ATP-binding cassette, sub-family A (ABC1), member 12.
      
 0.479
abcf1
ATP-binding cassette, sub-family F (GCN20), member 1.
   
  
 0.470
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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