Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rbbp8Uncharacterized protein. (670 aa)    
Predicted Functional Partners:
brca1
Uncharacterized protein.
    
 0.999
bard1
BRCA1 associated RING domain 1.
    
 0.998
mre11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 0.998
nbn
Nibrin.
    
 0.995
atm
Non-specific serine/threonine protein kinase.
    
 0.988
Exo1
Exonuclease 1.
    
 0.985
I3J6T4_ORENI
RAD50 homolog, double strand break repair protein.
    
 0.979
I3KS23_ORENI
AAA_15 domain-containing protein.
    
 0.979
rad50
RAD50 homolog, double strand break repair protein.
    
 0.979
sirt6
Sirtuin 6.
    
 0.976
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.