Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VAV3Vav guanine nucleotide exchange factor 3. (864 aa)    
Predicted Functional Partners:
cdc42
Cell division cycle 42.
   
 0.899
grb2
Growth factor receptor-bound protein 2b.
    
 0.853
LOC100710015
Uncharacterized protein.
    
  0.824
I3K4E0_ORENI
Uncharacterized protein.
    
  0.815
I3KQM2_ORENI
Phosphoinositide-3-kinase, regulatory subunit 3a (gamma).
    
  0.815
syk
Tyrosine-protein kinase.
   
 0.805
LOC100696446
Tyrosine-protein kinase.
   
 0.805
pik3cd
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 
 0.784
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 
 0.784
Pik3cb
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.
   
 
 0.784
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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