Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smsSpermine synthase. (364 aa)    
Predicted Functional Partners:
Amd1
S-adenosylmethionine decarboxylase proenzyme.
  
 
 0.981
smox
Spermine oxidase.
     
 0.974
srm
Exosome component 10; Belongs to the spermidine/spermine synthase family.
  
 
0.971
odc1
Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
  
 0.961
mtrr
5-methyltetrahydrofolate-homocysteine methyltransferase reductase.
   
 
 0.961
mtap
S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
  
 
 0.960
lacc1
Laccase (multicopper oxidoreductase) domain containing 1.
    
  0.918
LOC100690986
Si:dkey-275b16.2.
     
 0.911
LOC102079225
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase.
     
 0.911
agmat
Agmatine ureohydrolase (agmatinase); Belongs to the arginase family.
  
 
 0.870
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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