Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
LOC100697681Kelch-like family member 4. (731 aa)    
Predicted Functional Partners:
CUL3
Cullin 3; Belongs to the cullin family.
    
 0.838
LOC109194151
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 0.838
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.747
COL8A1
Collagen type VIII alpha 1 chain.
    
 0.715
rassf9
Ras association domain family member 9.
      
 0.694
bora
Bora aurora kinase A activator.
     
 0.657
sqstm1
Sequestosome 1.
    
 0.646
cops2
COP9 signalosome subunit 2.
    
 0.605
bbs1
Bardet-Biedl syndrome 1.
    
 0.602
cops4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis).
    
  0.596
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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