Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
rbl1Retinoblastoma-like 1 (p107). (1064 aa)    
Predicted Functional Partners:
tfdp1
Transcription factor.
   
 0.990
e2f1
E2F transcription factor 1.
   
 0.983
LOC100705578
E2F_TDP domain-containing protein.
   
 0.981
e2f4
E2F transcription factor 4.
   
 0.981
Ccne1
Cyclin E1; Belongs to the cyclin family.
   
 0.976
e2f2
Si:ch211-160f23.5.
   
 0.973
LOC100698323
Cyclin D2, a; Belongs to the cyclin family.
    
 0.973
LOC100707642
Cyclin D2, b; Belongs to the cyclin family.
    
 0.973
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.971
cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.971
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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