Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tirapToll-interleukin 1 receptor (TIR) domain containing adaptor protein. (291 aa)    
Predicted Functional Partners:
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
0.999
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.998
irak4
Interleukin-1 receptor-associated kinase 4.
   
 0.995
irak1
Interleukin-1 receptor-associated kinase 1.
   
 0.990
tollip
Toll interacting protein.
     
 0.955
Fadd
Uncharacterized protein.
    
 0.937
LOC102076024
TIR domain-containing protein; Belongs to the Toll-like receptor family.
   
 0.918
LOC100705953
Toll-like receptor 18.
   
 0.918
Tep1
Telomerase protein component 1 isoform X1.
    
   0.910
dele1
Uncharacterized protein.
   
 0.863
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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