Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hipk3Homeodomain interacting protein kinase 3b. (1313 aa)    
Predicted Functional Partners:
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.921
rassf5
Ras association domain family member 5.
    
 0.875
rassf3
Ras association domain family member 3.
    
  0.801
I3JW03_ORENI
Homeodomain interacting protein kinase 2.
     
  0.613
daxx
Death-domain associated protein.
    
 
 0.538
pin1
Peptidyl-prolyl cis-trans isomerase.
    
  0.516
mecp2
Methyl CpG binding protein 2.
    
 0.505
sumo1
Small ubiquitin-related modifier.
    
 0.499
ENSONIP00000069434
annotation not available
    
 0.465
cbfb
Core-binding factor subunit beta.
     
  0.464
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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