Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
trip12Thyroid hormone receptor interactor 12. (2065 aa)    
Predicted Functional Partners:
UBR1
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
 0.992
Ubr2
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
 0.992
rps27a
Ribosomal protein S27a.
    
 0.988
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
  0.985
usp7
Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.
   
 
 0.985
psmc5
Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.
    
 
 0.959
USP34
Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.
   
 
 0.953
ube4a
Ubiquitination factor E4A (UFD2 homolog, yeast).
   
 0.949
ube4b
Ubiquitination factor E4B, UFD2 homolog (S. cerevisiae).
   
 0.946
I3KDG2_ORENI
U-box domain containing 5.
   
 0.946
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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