Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
villVillin-like. (908 aa)    
Predicted Functional Partners:
cog6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
   
 
 0.687
cog8
Conserved oligomeric Golgi complex subunit 8; Belongs to the COG8 family.
    
 
 0.680
cog3
Component of oligomeric golgi complex 3.
    
 
 0.675
rplp1
Ribosomal protein, large, P1; Belongs to the eukaryotic ribosomal protein P1/P2 family.
      
 0.561
cap1
Adenylyl cyclase-associated protein; Belongs to the CAP family.
      
 0.559
twf1
Twinfilin actin-binding protein 1a.
   
 0.556
cog4
Component of oligomeric golgi complex 4.
    
 
 0.523
Smim7
Small integral membrane protein 7.
    
 
 0.523
pikfyve
Phosphoinositide kinase, FYVE finger containing.
     
  0.488
get3
ATPase get3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]
   
   0.480
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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