STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
insig1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (276 aa)    
Predicted Functional Partners:
scap
SREBF chaperone.
   
 0.913
chaf1b
Chromatin assembly factor 1, subunit B.
    
 
 0.836
LOC100697646
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.758
LOC100694446
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.730
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
   
 0.692
orc5
Origin recognition complex, subunit 5.
    
   0.688
orc3
Origin recognition complex, subunit 3.
    
 
 0.688
npc1
Niemann-Pick disease, type C1.
   
 0.688
LOC100711821
Anti-silencing function 1Ba histone chaperone.
   
 
 0.656
LOC100702465
Histone chaperone asf1b-B.
   
 
 0.656
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.