Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
shhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (415 aa)    
Predicted Functional Partners:
LOC100692939
Patched 2.
   
 0.997
ptch1
Patched 1.
   
 0.993
smo
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.989
disp1
Dispatched homolog 1 (Drosophila).
   
 0.987
Hhip
Hedgehog interacting protein.
    
 0.985
GAS1
Growth arrest-specific 1b.
    
 0.966
boc
BOC cell adhesion associated, oncogene regulated.
    
 0.961
cdon
Cell adhesion associated, oncogene regulated.
    
 0.961
gli3
Uncharacterized protein.
   
 0.948
I3J466_ORENI
Uncharacterized protein.
    
 0.946
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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