Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC100706225RAB4B, member RAS oncogene family. (232 aa)    
Predicted Functional Partners:
Rbsn
Rabenosyn, RAB effector.
    
 0.974
LOC100709430
RUN and FYVE domain containing 1.
    
 0.930
rufy2
RUN and FYVE domain containing 2.
    
 0.847
rabep1
Rabaptin, RAB GTPase binding effector protein 1.
    
 
 0.837
tbc1d16
TBC1 domain family, member 16.
    
 0.775
LOC100690604
Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.
    
 0.755
hgs
Hepatocyte growth factor-regulated tyrosine kinase substrate.
   
 0.723
stam
Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1.
    
 0.706
vps52
VPS52 subunit of GARP complex.
    
 0.668
ENSONIP00000026111
ADP-ribosylation factor 6b.
     
 0.647
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.