Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
strn4Striatin, calmodulin binding protein 4. (775 aa)    
Predicted Functional Partners:
LOC100701317
MOB family member 4, phocein.
   
 
 0.863
I3KP91_ORENI
Mitogen-activated protein kinase kinase 7.
   
  0.804
ppp2r1b
Protein phosphatase 2, regulatory subunit A, beta b.
   
 
 0.790
fgfr1op2
FGFR1 oncogene partner 2.
    
 
 0.788
slmap
Sarcolemma associated protein a.
   
 0.772
suox
Sulfite oxidase.
    
   0.762
LOC100709543
CTTNBP2 N-terminal like a.
   
 
 0.741
rnf8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
    
 
 0.740
LOC100696724
CTTNBP2 N-terminal like b.
   
 
 0.735
strip1
Striatin interacting protein 1.
   
 
 0.732
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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