Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dtlDenticleless E3 ubiquitin protein ligase homolog (Drosophila). (661 aa)    
Predicted Functional Partners:
ddb1
Damage-specific DNA binding protein 1.
    
 0.999
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.997
cdt1
Chromatin licensing and DNA replication factor 1.
   
 
 0.996
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.996
cops5
COP9 signalosome subunit 5.
    
 0.979
Cul4b
Cullin-4B.
    
 0.957
cul4a
Cullin 4A; Belongs to the cullin family.
    
 0.957
wdhd1
WD repeat and HMG-box DNA binding protein 1.
   
  
 0.952
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
  
 0.930
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
  
 0.929
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.