STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC10069166314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)    
Predicted Functional Partners:
CDC25B
Cell division cycle 25B.
    
 0.975
yap1
Yes-associated protein 1.
    
 0.763
I3JW49_ORENI
A-Raf proto-oncogene, serine/threonine kinase.
   
 0.753
braf
B-Raf proto-oncogene serine/threonine-protein kinase.
   
 0.753
raf1
Raf-1 proto-oncogene, serine/threonine kinase a.
   
 0.753
LOC100689869
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.
  
0.705
LOC100704829
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
  
0.705
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.694
ctnnb1
Catenin (cadherin-associated protein), beta 1.
   
 0.692
tsc2
Rap-GAP domain-containing protein.
    
 0.689
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.