Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC10069166314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)    
Predicted Functional Partners:
CDC25B
Cell division cycle 25B.
    
 0.899
yap1
Yes-associated protein 1.
    
 0.849
tsc2
Rap-GAP domain-containing protein.
    
 0.830
LOC100689869
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.
   
 0.816
LOC100704829
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
   
 0.816
ctnnb1
Catenin (cadherin-associated protein), beta 1.
   
 0.787
I3JW49_ORENI
A-Raf proto-oncogene, serine/threonine kinase.
    
 0.771
braf
B-Raf proto-oncogene serine/threonine-protein kinase.
    
 0.771
raf1
Raf-1 proto-oncogene, serine/threonine kinase a.
    
 0.771
akt1s1
AKT1 substrate 1 (proline-rich).
   
 0.753
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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