Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-expression
Experiments
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[Homology]
Score
ENSONIP00000008900Coiled-coil domain containing 106b. (212 aa)    
Predicted Functional Partners:
atf4
Activating transcription factor 4a.
    
   0.762
rspry1
Ring finger and SPRY domain containing 1.
      
 0.756
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.741
nudt13
Nucleoside diphosphate-linked moiety X motif 13 isoform X1.
      
 0.730
zc3h15
Zinc finger CCCH-type containing 15.
      
 0.717
snx15
Sorting nexin 15.
      
 0.699
fbxo9
F-box protein 9.
      
 0.634
gtf3c1
General transcription factor IIIC subunit 1.
      
 0.628
tpra1
Transmembrane protein, adipocyte asscociated 1.
      
 0.628
I3KV70_ORENI
B-block_TFIIIC domain-containing protein.
      
 0.628
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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