Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Aifm2Apoptosis inducing factor mitochondria associated 2. (353 aa)    
Predicted Functional Partners:
tmlhe
Trimethyllysine hydroxylase, epsilon.
      
 0.921
cdkal1
CDK5 regulatory subunit associated protein 1-like 1.
      
 0.907
suox
Sulfite oxidase.
   
 0.804
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.758
LOC100691569
Cytochrome b5 reductase 4.
     
 0.688
ggnbp2
Gametogenetin binding protein 2.
   
 
 0.658
chchd1
Coiled-coil-helix-coiled-coil-helix domain containing 1.
      
 0.629
LOC100702604
Zgc:92275.
  
 
 0.621
dhodh
Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
   
  
 0.619
mrps5
Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.
   
 
 0.616
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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