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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hpnHepsin; Belongs to the peptidase S1 family. (427 aa)    
Predicted Functional Partners:
hgf
Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.
  
 
 
0.657
mst1
Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.
   
 
 
0.623
LOC100704875
Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.
   
 
 
0.623
LOC100701740
Macrophage stimulating 1 receptor a.
    
 0.582
mst1r
Macrophage stimulating 1 receptor b.
    
 0.582
met
MET proto-oncogene, receptor tyrosine kinase.
    
 0.582
asah2
Neutral ceramidase.
      
 0.569
mbtps1
Membrane-bound transcription factor peptidase, site 1.
   
 
 0.554
angptl3
Angiopoietin-like 3.
   
 0.549
spint1
Serine peptidase inhibitor, Kunitz type 1 a.
    
 0.537
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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