Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
hpnHepsin; Belongs to the peptidase S1 family. (427 aa)    
Predicted Functional Partners:
LOC100692223
Serine peptidase inhibitor, Kunitz type, 2.
    
 0.648
asah2
Neutral ceramidase.
      
 0.631
mst1
Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.
     
 0.619
LOC100704875
Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.
     
 0.619
hgf
Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.
     
 0.619
agrn
Agrin.
   
 
 0.582
LOC100698618
Zinc finger and BTB domain containing 16b.
    
 
 0.558
amacr
Alpha-methylacyl-CoA racemase.
   
  
 0.547
spint1
Serine peptidase inhibitor, Kunitz type 1 a.
    
 0.546
LOC100695926
Uncharacterized protein.
    
 0.546
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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