ZNF516 protein (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

ZNF516

Zinc finger protein 516. (1104 aa)

Predicted Functional Partners:

Kdm1a

0.965

ENSONIP00000002644

0.852

Prdm16

0.852

ZADH2

0.788

TSHZ1

0.777

LOC100691448

0.771

Frmd6

0.741

znf407

0.713

cep70

0.711

LOC100698659

0.660

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000002644	Kdm1a	ENSONIP00000002644	ENSONIP00000048588	Si:ch211-263k4.2.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.853
ENSONIP00000002644	LOC100698659	ENSONIP00000002644	ENSONIP00000050726	Si:ch211-263k4.2.	Uncharacterized protein.	0.611
ENSONIP00000002644	Prdm16	ENSONIP00000002644	ENSONIP00000044154	Si:ch211-263k4.2.	LOW QUALITY PROTEIN: PR domain zinc finger protein 16.	0.872
ENSONIP00000002644	ZNF516	ENSONIP00000002644	ENSONIP00000009202	Si:ch211-263k4.2.	Zinc finger protein 516.	0.852
Frmd6	LOC100691448	ENSONIP00000000707	ENSONIP00000036380	FERM domain containing 6.	Teashirt zinc finger homeobox 1.	0.680
Frmd6	TSHZ1	ENSONIP00000000707	ENSONIP00000037684	FERM domain containing 6.	Teashirt zinc finger homeobox 1.	0.802
Frmd6	ZADH2	ENSONIP00000000707	ENSONIP00000009199	FERM domain containing 6.	Zinc binding alcohol dehydrogenase domain containing 2.	0.824
Frmd6	ZNF516	ENSONIP00000000707	ENSONIP00000009202	FERM domain containing 6.	Zinc finger protein 516.	0.741
Frmd6	cep70	ENSONIP00000000707	ENSONIP00000053341	FERM domain containing 6.	Centrosomal protein 70.	0.792
Frmd6	znf407	ENSONIP00000000707	ENSONIP00000009197	FERM domain containing 6.	Zinc finger protein 407.	0.829
Kdm1a	ENSONIP00000002644	ENSONIP00000048588	ENSONIP00000002644	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Si:ch211-263k4.2.	0.853
Kdm1a	LOC100698659	ENSONIP00000048588	ENSONIP00000050726	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Uncharacterized protein.	0.843
Kdm1a	Prdm16	ENSONIP00000048588	ENSONIP00000044154	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	LOW QUALITY PROTEIN: PR domain zinc finger protein 16.	0.852
Kdm1a	ZNF516	ENSONIP00000048588	ENSONIP00000009202	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Zinc finger protein 516.	0.965
LOC100691448	Frmd6	ENSONIP00000036380	ENSONIP00000000707	Teashirt zinc finger homeobox 1.	FERM domain containing 6.	0.680
LOC100691448	ZADH2	ENSONIP00000036380	ENSONIP00000009199	Teashirt zinc finger homeobox 1.	Zinc binding alcohol dehydrogenase domain containing 2.	0.767
LOC100691448	ZNF516	ENSONIP00000036380	ENSONIP00000009202	Teashirt zinc finger homeobox 1.	Zinc finger protein 516.	0.771
LOC100691448	cep70	ENSONIP00000036380	ENSONIP00000053341	Teashirt zinc finger homeobox 1.	Centrosomal protein 70.	0.641
LOC100691448	znf407	ENSONIP00000036380	ENSONIP00000009197	Teashirt zinc finger homeobox 1.	Zinc finger protein 407.	0.764
LOC100698659	ENSONIP00000002644	ENSONIP00000050726	ENSONIP00000002644	Uncharacterized protein.	Si:ch211-263k4.2.	0.611