Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
I3K8V7_ORENIE3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (304 aa)    
Predicted Functional Partners:
cacybp
Calcyclin binding protein.
    
 0.967
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.957
LOC100693960
Uncharacterized protein.
    
 0.876
LOC100691213
Uncharacterized protein; Belongs to the synuclein family.
    
 0.866
pink1
PTEN induced kinase 1.
    
 0.859
TOMM7
Mitochondrial import receptor subunit TOM7 homolog.
     
 0.814
tomm70
Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae).
     
 0.805
ENSONIP00000047919
Ubiquitin B.
     
 0.798
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
     
  0.789
rps27a
Ribosomal protein S27a.
     
  0.789
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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