Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
npr1Guanylate cyclase. (1067 aa)    
Predicted Functional Partners:
LOC100705260
Uncharacterized protein.
    
 0.968
I3KND2_ORENI
Uncharacterized protein.
    
 0.957
pde3b
Phosphodiesterase.
   
 0.913
pde6g
Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b.
     
 0.909
nppc
Natriuretic peptide C.
    
 0.895
LOC100706644
Phosphodiesterase.
   
 0.889
pde6c
Phosphodiesterase.
   
 0.889
I3J8W3_ORENI
Phosphodiesterase.
   
 0.889
I3JFY9_ORENI
Phosphodiesterase.
   
 0.885
LOC100710868
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X4.
   
 0.885
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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