Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LOC100702638Poly (ADP-ribose) polymerase family, member 12b. (474 aa)    
Predicted Functional Partners:
nudcd1
NudC domain containing 1.
    
   0.760
Rnf166
RING finger protein 166 isoform X1.
    
  0.708
mtrr
5-methyltetrahydrofolate-homocysteine methyltransferase reductase.
      
 0.679
LOC100711295
Si:ch73-252i11.1.
   
 
 0.665
parp1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.628
LOC102077663
KH and NYN domain containing.
    
 
 0.538
LOC100697573
Prokineticin receptor 1b; Belongs to the G-protein coupled receptor 1 family.
      
 0.536
LOC100693113
Prokineticin receptor 1a; Belongs to the G-protein coupled receptor 1 family.
      
 0.536
Helz2
Uncharacterized protein.
   
 
 0.481
LOC100704951
Poly [ADP-ribose] polymerase.
   
 
 0.460
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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