Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
irf5Interferon regulatory factor 5. (474 aa)    
Predicted Functional Partners:
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.975
LOC109202766
Monocyte chemotactic protein 1B.
     
  0.916
ENSONIP00000078528
C-C motif chemokine 17.
     
  0.902
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.654
mavs
CARD_2 domain-containing protein.
    
 0.652
ikbke
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
    
 0.644
grhl3
Grainyhead-like transcription factor 3.
    
 
 0.623
LOC100703629
Toll-like receptor 3; Belongs to the Toll-like receptor family.
   
 
 0.615
LOC100704899
Interferon regulatory factor.
   
 0.615
LOC106098454
E3 ubiquitin/ISG15 ligase TRIM25 isoform X1.
    
 0.600
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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