Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Brix1Brix domain containing 2. (358 aa)    
Predicted Functional Partners:
ebna1bp2
EBNA1 binding protein 2.
   
 
 0.998
pum3
Pumilio RNA-binding family member 3.
   
 
 0.996
mrto4
Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
   
 
 0.995
rpf2
Ribosome production factor 2 homolog.
   
 
 0.995
nip7
60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.
   
 
 0.994
nop58
NOP58 ribonucleoprotein homolog (yeast).
   
 
 0.993
LOC100711132
Nucleolar protein interacting with the FHA domain of MKI67.
   
 
 0.993
mak16
Protein MAK16 homolog; Belongs to the MAK16 family.
   
 
 0.993
noc2l
NOC2-like nucleolar associated transcriptional repressor.
   
 
 0.992
rpf1
Ribosome production factor 1 homolog.
   
 
 0.992
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.