Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rad1RAD1 homolog (S. pombe). (279 aa)    
Predicted Functional Partners:
hus1
Checkpoint protein; Belongs to the HUS1 family.
    
 0.998
rad9a
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.993
rad17
RAD17 checkpoint clamp loader component.
   
 0.993
rad9b
RAD9 checkpoint clamp component B.
    
 0.993
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.991
rhno1
Uncharacterized protein.
   
 0.989
rfc4
Replication factor C (activator 1) 4.
   
 0.985
atm
Non-specific serine/threonine protein kinase.
    
 0.958
topbp1
DNA topoisomerase II binding protein 1.
    
 0.953
ercc4
Excision repair cross-complementation group 4.
   
 0.946
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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