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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rad1RAD1 homolog (S. pombe). (279 aa)    
Predicted Functional Partners:
hus1
Checkpoint protein; Belongs to the HUS1 family.
    
 0.999
rad9a
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.996
rad9b
RAD9 checkpoint clamp component B.
    
 0.996
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.993
rad17
RAD17 checkpoint clamp loader component.
   
 0.982
rfc4
Replication factor C (activator 1) 4.
   
 0.980
slf1
BRCT domain-containing protein.
    
 0.977
rfc5
Replication factor C (activator 1) 5.
   
 0.964
rfc2
Replication factor C (activator 1) 2.
   
 0.961
rfc3
Replication factor C (activator 1) 3.
   
 0.960
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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