Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC100692643Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (652 aa)    
Predicted Functional Partners:
ctnnb1
Catenin (cadherin-associated protein), beta 1.
   
 0.929
LOC100693960
Uncharacterized protein.
   
  0.919
LOC100710423
Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family.
     
  0.916
LOC100709535
Leucine zipper, putative tumor suppressor 1.
    
   0.762
UNC79
Unc-79 homolog, NALCN channel complex subunit.
    
 0.652
I3JMM6_ORENI
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B.
    
 
 0.570
dyrk1a
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b.
    
 
 0.570
I3KVH4_ORENI
Uncharacterized protein.
    
 0.539
I3KNP1_ORENI
Uncharacterized protein.
    
 0.539
LOC100700713
SH3 and multiple ankyrin repeat domains 3a.
    
 0.539
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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