Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
twnkTwinkle mtDNA helicase. (720 aa)    
Predicted Functional Partners:
polg
Polymerase (DNA directed), gamma.
   
 
 0.967
polg2
DNA polymerase subunit gamma-2, mitochondrial isoform X1.
     
 0.964
cpox
Coproporphyrinogen oxidase.
    
   0.913
polrmt
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.
   
 
 0.904
nubpl
Nucleotide binding protein-like.
    
 
 0.893
ssbp1
Single-stranded DNA binding protein 1.
   
 
 0.892
tfam
Transcription factor A, mitochondrial.
     
 0.850
galt
Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
     
  0.808
galm
Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.
     
  0.808
Endog
Endonuclease.
    
 
 0.790
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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