STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
twnkTwinkle mtDNA helicase. (720 aa)    
Predicted Functional Partners:
ssbp1
Single-stranded DNA binding protein 1.
   
  
 0.703
polg
Polymerase (DNA directed), gamma.
   
  
 0.702
tfam
Transcription factor A, mitochondrial.
      
 0.647
polrmt
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.
   
  
 0.636
polg2
DNA polymerase subunit gamma-2, mitochondrial isoform X1.
      
 0.636
mgme1
Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family.
      
 0.588
dna2
DNA replication helicase/nuclease 2.
      
 0.586
LOC100705170
Deoxyguanosine kinase.
      
 0.585
rnaseh1
Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
      
 0.584
rmnd1
Required for meiotic nuclear division 1 homolog.
      
 0.583
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.