Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC100695973Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (426 aa)    
Predicted Functional Partners:
pafah1b3
Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit.
    
 0.987
LOC100698525
Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2.
    
 0.987
nudc
NudC nuclear distribution protein.
   
 0.979
pla2g7
Platelet-activating factor acetylhydrolase.
     
 0.950
ckap5
Cytoskeleton associated protein 5.
    
 0.935
LOC100698203
Phospholipase A(2).
     
 0.922
LOC100702365
Uncharacterized protein.
     
 0.919
LOC100706532
Group XIIB secretory phospholipase A2-like protein isoform X2.
     
 0.919
pla2g4a
Phospholipase A2.
   
 
  0.917
LOC100693391
Lysophosphatidylcholine acyltransferase 4.
     
  0.916
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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