Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
pdha1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (393 aa)    
Predicted Functional Partners:
pdhb
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.999
dlat
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.996
dld
Dihydrolipoyl dehydrogenase.
   
 0.995
pdhx
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
 
 0.995
bckdhb
Branched chain keto acid dehydrogenase E1 subunit beta.
 
 0.978
h6pd
Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase).
   
 0.955
PC
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
   
 0.945
LOC100694503
Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.
   
 
 0.944
LOC100694281
L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.943
LOC100534427
L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.943
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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