mcm5 protein (Oreochromis niloticus) - STRING interaction network

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mcm5

DNA helicase; Belongs to the MCM family. (737 aa)

Predicted Functional Partners:

orc1

0.999

mcm4

0.999

cdt1

0.999

mcm6

0.999

mcm2

0.999

cdc45

0.999

MCM7

0.999

mcm3

0.999

orc5

0.998

orc3

0.996

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	cdc45	ENSONIP00000055028	ENSONIP00000043787	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.998
MCM7	cdt1	ENSONIP00000055028	ENSONIP00000016535	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Chromatin licensing and DNA replication factor 1.	0.999
MCM7	mcm2	ENSONIP00000055028	ENSONIP00000032842	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	mcm3	ENSONIP00000055028	ENSONIP00000057614	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	mcm4	ENSONIP00000055028	ENSONIP00000011994	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	mcm5	ENSONIP00000055028	ENSONIP00000010364	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	mcm6	ENSONIP00000055028	ENSONIP00000019721	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	orc1	ENSONIP00000055028	ENSONIP00000009832	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.995
MCM7	orc3	ENSONIP00000055028	ENSONIP00000004552	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Origin recognition complex, subunit 3.	0.995
MCM7	orc5	ENSONIP00000055028	ENSONIP00000000121	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Origin recognition complex, subunit 5.	0.992
cdc45	MCM7	ENSONIP00000043787	ENSONIP00000055028	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.998
cdc45	cdt1	ENSONIP00000043787	ENSONIP00000016535	CDC45 cell division cycle 45 homolog (S. cerevisiae).	Chromatin licensing and DNA replication factor 1.	0.990
cdc45	mcm2	ENSONIP00000043787	ENSONIP00000032842	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA helicase; Belongs to the MCM family.	0.999
cdc45	mcm3	ENSONIP00000043787	ENSONIP00000057614	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA helicase; Belongs to the MCM family.	0.998
cdc45	mcm4	ENSONIP00000043787	ENSONIP00000011994	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA helicase; Belongs to the MCM family.	0.999
cdc45	mcm5	ENSONIP00000043787	ENSONIP00000010364	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA helicase; Belongs to the MCM family.	0.999
cdc45	mcm6	ENSONIP00000043787	ENSONIP00000019721	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA helicase; Belongs to the MCM family.	0.998
cdc45	orc1	ENSONIP00000043787	ENSONIP00000009832	CDC45 cell division cycle 45 homolog (S. cerevisiae).	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.990
cdc45	orc3	ENSONIP00000043787	ENSONIP00000004552	CDC45 cell division cycle 45 homolog (S. cerevisiae).	Origin recognition complex, subunit 3.	0.996
cdc45	orc5	ENSONIP00000043787	ENSONIP00000000121	CDC45 cell division cycle 45 homolog (S. cerevisiae).	Origin recognition complex, subunit 5.	0.994