sigirr protein (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

sigirr

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain. (518 aa)

Predicted Functional Partners:

UNC79

0.759

LOC100693282

0.708

myd88

0.674

LOC109194203

0.581

tollip

0.572

irak1

0.537

hpdl

0.535

traf6

0.528

LOC100692890

0.521

LOC100698800

0.519

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100692890	sigirr	ENSONIP00000049343	ENSONIP00000010407	RAN binding protein 2.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.521
LOC100693282	myd88	ENSONIP00000014133	ENSONIP00000007350	Interleukin-1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.475
LOC100693282	sigirr	ENSONIP00000014133	ENSONIP00000010407	Interleukin-1.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.708
LOC100698800	sigirr	ENSONIP00000000269	ENSONIP00000010407	Fibrinogen C-terminal domain-containing protein.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.519
LOC109194203	hpdl	ENSONIP00000036928	ENSONIP00000020178	Aldo_ket_red domain-containing protein.	4-hydroxyphenylpyruvate dioxygenase.	0.597
LOC109194203	sigirr	ENSONIP00000036928	ENSONIP00000010407	Aldo_ket_red domain-containing protein.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.581
UNC79	sigirr	ENSONIP00000025373	ENSONIP00000010407	Unc-79 homolog, NALCN channel complex subunit.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.759
hpdl	LOC109194203	ENSONIP00000020178	ENSONIP00000036928	4-hydroxyphenylpyruvate dioxygenase.	Aldo_ket_red domain-containing protein.	0.597
hpdl	sigirr	ENSONIP00000020178	ENSONIP00000010407	4-hydroxyphenylpyruvate dioxygenase.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.535
irak1	myd88	ENSONIP00000070688	ENSONIP00000007350	Interleukin-1 receptor-associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.998
irak1	sigirr	ENSONIP00000070688	ENSONIP00000010407	Interleukin-1 receptor-associated kinase 1.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.537
irak1	tollip	ENSONIP00000070688	ENSONIP00000045642	Interleukin-1 receptor-associated kinase 1.	Toll interacting protein.	0.967
irak1	traf6	ENSONIP00000070688	ENSONIP00000057481	Interleukin-1 receptor-associated kinase 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
myd88	LOC100693282	ENSONIP00000007350	ENSONIP00000014133	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Interleukin-1.	0.475
myd88	irak1	ENSONIP00000007350	ENSONIP00000070688	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Interleukin-1 receptor-associated kinase 1.	0.998
myd88	sigirr	ENSONIP00000007350	ENSONIP00000010407	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.674
myd88	tollip	ENSONIP00000007350	ENSONIP00000045642	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll interacting protein.	0.980
myd88	traf6	ENSONIP00000007350	ENSONIP00000057481	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.998
sigirr	LOC100692890	ENSONIP00000010407	ENSONIP00000049343	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	RAN binding protein 2.	0.521
sigirr	LOC100693282	ENSONIP00000010407	ENSONIP00000014133	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	Interleukin-1.	0.708