Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fan1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1106 aa)    
Predicted Functional Partners:
fancd2
FA complementation group D2.
    
 0.999
Mlh1
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).
   
 0.998
pms2
PMS1 homolog 2, mismatch repair system component.
   
 0.997
pms1
PMS1 homolog 1, mismatch repair system component.
   
 0.987
fanci
FA complementation group I.
    
 0.951
fancm
Uncharacterized protein.
    
 0.895
dclre1a
DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae).
    
 0.880
mtmr10
Myotubularin related protein 10.
      
 0.866
eme1
Essential meiotic structure-specific endonuclease 1.
     
 0.863
LOC100708044
SLX1 homolog B, structure-specific endonuclease subunit.
   
 
 0.860
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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