Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1182 aa)    
Predicted Functional Partners:
shox2
Short stature homeobox 2.
      
 0.678
LOC100695692
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform X1.
  
  
 
0.557
LOC100706079
Cyclic nucleotide-binding domain-containing protein.
  
  
 
0.556
HCN2
Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.
  
  
 
0.552
LOC100711672
Cyclic nucleotide-binding domain-containing protein.
  
  
 
0.551
LOC100711592
Hyperpolarization activated cyclic nucleotide-gated potassium channel 1.
  
  
 
0.550
hcn4
Hyperpolarization activated cyclic nucleotide-gated potassium channel 4.
  
  
 
0.549
LOC100712218
Hyperpolarization activated cyclic nucleotide-gated potassium channel 3.
  
  
 
0.546
nkx2-5
NK2 homeobox 5.
   
  
 0.525
LOC100698703
T-box transcription factor 5a.
   
  
 0.525
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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