Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NET1Uncharacterized protein. (583 aa)    
Predicted Functional Partners:
ap2m1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
    
 0.620
magi1
Membrane associated guanylate kinase, WW and PDZ domain containing 1b.
    
   0.608
I3KKZ0_ORENI
Membrane associated guanylate kinase, WW and PDZ domain containing 1a.
    
   0.608
ap2s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
   
  0.574
LOC100704432
Centromere protein S.
    
 0.543
wscd2
WSC domain containing 2.
    
 0.543
LOC100709793
WSC domain containing 1b.
    
 0.543
LOC100698045
Somatostatin-1B.
    
 0.543
LOC100694803
Ras homolog family member Cb.
    
 0.514
LOC100693083
Uncharacterized protein.
    
 0.514
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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