Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (184 aa)    
Predicted Functional Partners:
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
    
 0.981
cul1
Cullin 1b; Belongs to the cullin family.
    
 0.972
Ccne1
Cyclin E1; Belongs to the cyclin family.
   
 0.971
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.969
ccna2
Cyclin A2; Belongs to the cyclin family.
   
 0.968
ccna1
Cyclin A1; Belongs to the cyclin family.
   
 0.968
skp1
S-phase kinase-associated protein 1; Belongs to the SKP1 family.
    
 0.967
cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.964
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.961
LOC100698323
Cyclin D2, a; Belongs to the cyclin family.
   
 0.960
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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